This is similar to https://github.com/handsontable/handsontable/issues/3082 . Most people I know are using Immutable.js and lodash to do formula computations in handsontable.
However, HOT does not maintain compatibility with ES6 functions and conventions - and so it is very difficult to integrate HOT with any new library.
A good way to figure out the ES6 conventions are https://github.com/facebook/immutable-js/wiki/Upgrading-to-Immutable-v3