I created a similar issue a couple weeks ago about copying large number of rows which was fixed with the upgrade to 15.1.0 from 15.0.1. However, I have discovered that the same issue still exists when trying to copy a large number of columns at once. Essentially, if you select a cell, then shift select a several dozen cells to the right, the copy will simply not work. If you try to paste afterwards you will paste whatever was originally in your clipboard.
Here is a basic jsfiddle that I was able to reproduce the issue in: https://jsfiddle.net/wcuv7d68/2/
simply select a cell, scroll all the way to the right and shift click another cell, then try to paste it and it will not work.